Chemistry of atorvastatin calcium

The chemical name of atorvastatin calcium is (3R, 5R) - 7 - [2 - (4-fluorophenyl) - 3-phenyl-4 - (phenylcarbamoyl) - 5-isopropyl-pyrrole-1-yl] - 3,5-dihydroxyheptanoate calcium trihydrate, which is a new tissue selective synthetic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG GOA) and can reduce the level of low-density lipoprotein cholesterol in blood circulation, Inhibit the synthesis of cholesterol in plasma, so as to have the effect of lowering blood ester. Compared with other statins, atorvastatin calcium has the characteristics of strong hypolipidemic effect, long action time, fast onset, safety and high efficiency. This makes atorvastatin calcium become the best-selling drug in the treatment of cardiovascular and cerebrovascular diseases. At the same time, the optimization of the drug has become the focus of scientific research. On the basis of reading a large number of literatures, this paper briefly describes the pathogenesis of cardiovascular and cerebrovascular diseases and the research status of lipid-lowering drugs, compares the existing synthetic routes of atorvastatin calcium, and finally determines to use Paal Knorr method to prepare the key intermediate L1 of atorvastatin calcium, which is hydrolyzed to protect and then salt to prepare atorvastatin calcium.

2020 is an extraordinary year. Under the raging of the new crown virus, the development of enterprises at home and abroad has been seriously affected. People's physical and mental health and the healthy development of enterprises have been affected. The novel coronavirus pneumonia, novel coronavirus pneumonia, novel coronavirus pneumonia, is widely used and cheap. Statins can significantly reduce the mortality rate of new crown pneumonia patients. Atorvastatin calcium is just in line. Atorvastatin calcium is used in the preparation of new crown pneumonia drugs. Atorvastatin can alleviate the new crown pneumonia mechanism by weakening the ability of COVID 19 virus to invade human cells through ACE2. So as to inhibit the replication of covid-19 virus.

For atorvastatin calcium, the future can be expected! Welcome domestic and foreign partners to negotiate.







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