Atorvastatin calcium, named (3R, 5R) - 7 - [2 - (4-fluorophenyl) - 3-phenyl-4 - (phenylcarbamoyl) - 5-isopropyl-pyrrole-1-yl] - 3,5-dihydroxyheptanate calcium trihydrate, is a new tissue selective inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase (hmg-goa), which can reduce the level of low-density lipoprotein cholesterol in the blood circulation, It can inhibit the synthesis of cholesterol in the plasma, so as to reduce the blood lipid. Compared with other statins, atorvastatin calcium has a strong effect on reducing blood lipid, long acting time, rapid onset, safety and high efficiency. This makes atorvastatin calcium become the best-selling drug in the treatment of cardiovascular and cerebrovascular diseases. At the same time, the optimization of the drug has become the focus of scientific research. On the basis of reading a large number of literatures, the pathogenesis of cardiovascular and cerebrovascular diseases and the research status of antihyperlipidemic drugs were briefly described, and the existing synthetic routes of atorvastatin calcium were compared. Finally, the key intermediate L1 of atorvastatin calcium was prepared by Paal Knorr method, and then hydrolyzed to protect and salt to prepare atorvastatin calcium.
2020 is an extraordinary year. Under the new coronavirus, the development of enterprises at home and abroad has been seriously impacted, people's physical and mental health, and the healthy development of enterprises have been affected. Novel coronavirus pneumonia is novel coronavirus pneumonia, novel coronavirus pneumonia is widely used and cheap. Statins can significantly reduce the mortality of new crown pneumonia patients. Atorvastatin calcium is just in line. Atorvastatin calcium can be used in the treatment of new crown pneumonia. Atorvastatin can alleviate the new crown pneumonia mechanism by weakening the ability of COVID 19 virus to invade human cells through ACE2, thereby inhibiting COVI D ￣ 19 virus replication.
For atorvastatin calcium, the future can be expected! Welcome domestic and foreign partners to negotiate.