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Atorvastatin calcium chemistry
Add time:2023-03-20

The chemical name of atorvastatin calcium is (3R, 5R) - 7 - [2 - (4-fluorophenyl) - 3-phenyl-4 - (phenylcarbamoyl) - 5-isopropylpyrrol-1-yl] - 3,5-dihydroxyheptanoate calcium trihydrate. It is a novel tissue selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-GoA) synthesis, which can reduce the level of low density lipoprotein cholesterol in the blood circulation and inhibit the synthesis of cholesterol in plasma, thereby achieving a therapeutic effect of lowering blood lipids. Compared to other statins, atorvastatin calcium has a strong lipid-lowering effect, a long action time, and is characterized by rapid onset, safety, and efficiency. This has led to atorvastatin calcium becoming a popular drug for the treatment of cardiovascular and cerebrovascular diseases. At the same time, the optimization of the drug has also become the focus of research workers. On the basis of reading a large number of literature, this article briefly describes the pathogenesis of cardiovascular and cerebrovascular diseases and the current research status of lipid-lowering drugs, and compares the existing synthetic routes of atorvastatin calcium. Finally, it is determined to use the Paal Knorr method to prepare the key intermediate L1 of atorvastatin calcium, which is then hydrolyzed and deprotected before being salted to produce atorvastatin calcium.

The year 2020 is an extraordinary year. Under the ravages of COVID-19, the development of enterprises at home and abroad has been severely impacted. The physical and mental health of people and the healthy development of enterprises have been affected to a certain extent. The widely used and inexpensive old drugs statins may significantly reduce the mortality of hospitalized patients with COVID-19, while atorvastatin calcium is just on the list. The application of atorvastatin calcium in the preparation of drugs to treat COVID-19. The mechanism of atorvastatin calcium to alleviate COVID-19 is to weaken the ability of COVID-19 virus to invade human cells throug.

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